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"The impact of different environments on HP infection rate" topic opening report

The question was raised by my father who was a doctor. I have a strong interest in medicine. Recently, I learned from some books that Hp is a causative factor of gastritis, gastric ulcer, and even gastric cancer. By looking at the information, I learned more about HP.
1. Background As early as a century ago, it was discovered that gastric memory is not considered in a spiral microorganism due to long-term failure to separate. It was not until 1983 that Australian scholars discovered curved bacteria from human gastric biopsy specimens. The name evolved and was named Helicobacter pylori in 1987 and was translated into Helicobacter pylori in 1991. Since the separation of Hp, scholars from various countries have conducted a lot of research on it. Chronic gastritis, peptic ulcer and functional dyspepsia have been confirmed to be related to this. More studies have confirmed that gastric cancer also has a certain relationship with Hp. Therefore, countries spend a lot of manpower and material resources on HP's inspection and treatment. In 1994, Hp was identified as a oral carcinogen by the WTO International Cancer Research Institute. From this, I thought whether I could find an effective preventive measure to prevent Hp infection. After transformation, it becomes the current topic - the impact of different environments on Hp infection rate.
2. Value There is information that Hp is transmitted through a mouthful or a feces. China has a large population and a relatively dense population in the living and working environment, which provides certain conditions for the infection of Hp. However, there is little research on the Hp infection rate of people working under different conditions, such as people with good work and living conditions and poor working and living conditions. If the work and living environment does affect the infection rate of Hp, then it will provide a certain theoretical basis for the prevention and treatment of Hp.
3. Studies on similar subjects have revealed that there is very little research on the Hp infection rate of different economic levels, working environment and living environment. Some people have investigated the difference in Hp infection rates between different economic levels and the same occupation, which have provided reference materials for my research.
4. The feasibility of the study is scientific. Strictly select the research object, the instrument is precise and effective. There is data indicating that the infection rate of Hp in developing countries is higher than in developed countries, especially in children, and the Hp infection rate increases sharply with age. China is in the middle of developing countries and is a highly infected country. Therefore, it is more important to study the prevention of Hp infection.
Innovative. At present, no comparison has been made between Hp infection rates in different work and living environments. My topic can provide some reference for research in this field.
Subjective and objective conditions of research
1. Member strengths I have a strong interest in medicine and biology, and have a lot of understanding. Doing things rigorously, after proper training, it can be used for the operation of precision laboratory instruments and the statistical processing of experimental data. Have the logical thinking ability to analyze the experimental data.
2. Data and equipment testing was conducted at 301 Hospital, which has a high-precision gas isotope ratio mass spectrometer for research. The laboratory has accumulated thousands of cases of experience in this work.
3. tutor
301 Hospital Cai Changhao, deputy chief physician, associate professor.
Research Projects and Research Methods: Patients who have been examined by the hospital for Hp examination, exclude patients who have undergone doctors' construction examinations, and register the patient's work nature, family living environment, social living environment, etc. by means of questionnaires, and divide them into two groups. Group of 30 people. One group has a high economic level and a superior working and living environment; the other group has a low economic level and a relatively poor working and living environment.
1. The effect of different working conditions on Hp infection rate Age: Years.
Education level: below high school or above university.
Work unit: company or marketing.
Economic income: less than 2,000 yuan, 2000 to 5,000 yuan or more than 5,000 yuan.
Nature of work: mental or physical labor.
Work area daily traffic: more or less.
Office conditions; office or market.
Home environment: apartments, dormitory boxes or bungalows.
Transportation: Private cars, public transportation or bicycles.
Medical conditions: public hospitals or hospitals of choice.
Conditions for seeing a doctor: Symptoms, regular health checks.
For your own health: value or not.
2. Subjects were enrolled in the standard age range of 20-35 years.
No antibiotics have been taken for the past two weeks.
Acidic drugs have not been used for the past two weeks.
No history of stomach surgery.
No history of mental disorders, can cooperate with the completion of the investigation.
3. After the research method determines the selected subjects, fill in the research informed form.
Go to the hospital for Helicobacter pylori testing as required.
Detection method: 13C urease breath test method.
Steps: Check the daily fasting, take the standard test meal in the examination room, and take the specimen according to the uniform standard.
Basic principle: Under normal circumstances, there is very little bacterial growth in the stomach, no urease activity, but rich in urease, which can decompose endogenous and exogenous urea into NH3 and CO2, the latter in the upper part of the small intestine mucosa Absorption into the blood circulation, and finally exhaled from the lungs, so a certain dose of isotope-labeled urea, a high-sensitivity specific instrument to detect exhaled gas containing 13C-labeled CO2, can determine whether there is Hp infection in the stomach. 13C-urea is a stable isotope, has no radiation effect, and is harmless to the human body. The detection sensitivity and specificity of 13C-UBT for Hp is 90%-100%, and UBT is superior to histological examination in clinical routine examination of Hp.
4. The test plan screening subjects, 13C urease breath test test for 2 to 3 months.
The experimental results were analyzed and analyzed for 1 to 2 months.
Write a thesis for 2 months.
5. Statistical processing All test results were statistically analyzed.
Expected results There may be differences in Hp infection rates between the two groups. The analysis can summarize the impact of the environment on HP infection rate, and put forward corresponding prevention and treatment opinions.
Completed 1 paper report.
References "Gastroenterology", "Basic and Clinical Helicobacter Pylori Infection".

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